Diverse Sequences within Tlr Elements Target Programmed DNA Elimination in Tetrahymena thermophila
نویسندگان
چکیده
منابع مشابه
Diverse sequences within Tlr elements target programmed DNA elimination in Tetrahymena thermophila.
Tlr elements are a novel family of approximately 30 putative mobile genetic elements that are confined to the germ line micronuclear genome in Tetrahymena thermophila. Thousands of diverse germ line-limited sequences, including the Tlr elements, are specifically eliminated from the differentiating somatic macronucleus. Macronucleus-retained sequences flanking deleted regions are known to contai...
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The maintenance of chromosome integrity is crucial for genetic stability. However, programmed chromosome fragmentations are known to occur in many organisms, and in the ciliate Tetrahymena the five germline chromosomes are fragmented into hundreds of minichromosomes during somatic nuclear differentiation. Here, we showed that there are different fates of these minichromosomes after chromosome b...
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ژورنال
عنوان ژورنال: Eukaryotic Cell
سال: 2003
ISSN: 1535-9778,1535-9786
DOI: 10.1128/ec.2.4.678-689.2003